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Here is a link to CIMS India Drug Information eBook in pdb format.:) version P.S. The mediafire link would be the easiest to download from if you don't have a rapidsahre or easyshare account. There is or the free yBook. Also visit my Other Post Indian Drugs Brand Names Free Android Mobile The eBook of CIMS India contains details about medical drugs. For over 50 years, MIMS has provided trusted and relevant clinical information for over two million healthcare professionals in Asia. Designed for busy.


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tetraedge.info - Free ebook download as PDF File .pdf), Text File .txt) or a drugs part 1 - Dr John CIMS India Drugs Reference. Manufacturer; Contents; CIMS Class; ATC Classification; Presentation/Packing CIMS Class · Antiemetics. ATC Classification DOWNLOAD FREE MIMS Apps. Search drug, interactions and image information in China, Hong Kong, Taiwan, Malaysia, S'pore, Philippines, Vietnam, Thailand, Indonesia, India & USA.

John http: But note that medical drugs details are updated atleast monthly by organisations like MIMS and so this book is already very outdated by the time you read this. Kindly refer to an up-to-date and current drug information book for any important decisions. This eBook includes details of about generic drugs available in India. This is for demonstration purposes only and is not intended for application in life threating or serious medical situations.

Share your thoughts with other customers. Write a product review. Customer images. See all customer images. Top Reviews Most recent Top Reviews. There was a problem filtering reviews right now. Please try again later. Paperback Verified Purchase. Still, this book will be useful when internet is not available. I always purchase a fresh copy every year. Very helpful especially because of the updated list and cost of different brands of drugs in market.

One person found this helpful. It's Okay. Letters are too smalls , except the MR Endorsements obviously lol.

Automate waste,the edition is old one,but I bought it for rs , In my city. All the pages came out, and even i cant be able to attach the pages of the book after trying several times Special Patients with sunburn, eczema. Avoid Precautions excessive exposure to sunlight or UV irradiation.

Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid.

Adverse Drug Mild skin irritation, scaling, erythema, cutaneous dryness, Reactions sensations of stinging and burning, pruritus. Drug Interactions Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.

Mechanism of Adapalene binds to specific retinoic acid nuclear receptors Action which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Minimal topical. Haemodialysis patients: Overdosage Monitor for signs of toxicity, apply supportive treatment when necessary. Contraindications Lactation. Special Pregnancy; elderly; child; renal or hepatic impairment. HIV Precautions antibody testing to be performed before initiation due to possible resistance development in untreated HIV infection.

Increased risk of hepatotoxicity in females, obese patients and with prolonged treatment. Monitor renal function every 3 mth; hepatitis B biochemical, viral and serological markers every 6 mth and LFTs. Discontinue therapy if liver function worsens, severe hepatomegaly, steatosis or unexplained metabolic or lactic acidosis.

Monitor hepatic function for several mth in patients whose antihepatitis therapy is discontinued as acute exacerbations of hepatitis may occur. Adverse Drug Nausea, dyspepsia, abdominal pain, flatulence, diarrhoea, Reactions asthenia, headache. Pruritus, skin rashes, and respiratory effects e. Lactic acidosis, severe hepatomegaly with steatosis, hepatotoxicity, nephrotoxicity. Drug Interactions Increased risk of nephrotoxicity with nephrotoxic drugs e. Ibuprofenincreases bioavailability of adefovir.

Food Interaction Increased risk of hepatotoxicty with alcohol in hepatitis B infection. Mechanism of Adefovir dipivoxil is an acyclic nucleoside reverse transciptase Action inhibitor. The diester function is hydrolyzed and subsequently phosphorylated to the active adefovir diphosphate.

It can be used in patients with lamivudine-resistant hepatitis B. Rapidly converted to adefovir after oral admin. Plasma concentration peaks after 0. Widely distributed to body tissues.

Protein binding: Note that there are some more drugs interacting with adefovir dipivoxil adefovir dipivoxil adefovir dipivoxil brands available in India Always prescribe with Generic Name: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after minutes if necessary, then 12 mg after a further minutes.

Avoid increments if high level AV block occurs at any particular dose. Max Dosage: Intravenous Paroxysmal supraventricular tachycardia Adult: Intravenous Myocardial imaging Adult: Inject radionuclide 3 minute after infusion. Contraindications 2nd or 3rd degree AV block and sick sinus syndrome unless pacemaker fitted , asthma, hypersensitivity.

Special Pregnancy; heart transplant patients; patients on Precautions dipyridamole lower initial dose of adenosine 0. Adverse Drug Facial flushing, palpitations, chest pain, bradycardia, Reactions sweating, hypotension, dyspnoea, choking sensation, headache, lightheadedness, tingling, numbness, neck and back pain, nausea, metallic taste.

ECG changes suggestive of rhythm disturbances. Drug Interactions Adenosine effects antagonised by methylxanthines like caffeine, theophylline, etc. Concomitant carbamazepine may increase the risk of heart block. Adenosine effects are potentiated by dipyridamole.

Mechanism of Adenosine acts rapidly to slow down conduction through the Action AV node via the A1 receptors. It also mediates peripheral and coronary vasodilatation by stimulating the A2 receptors. Rapidly taken up into the erythrocytes and vascular endothelial cells.

Metabolised to adenosine monophosphate and inosine. Plasma half-life: Note that there are some more drugs interacting with adenosine adenosine adenosine brands available in India Always prescribe with Generic Name: For cystic echinococcosis, up to 3 treatment cycles of 28 days each may be given with 14 treatment-free days in between cycles. For alveolar echinococcosis, treatment cycles of 28 days each with 14 treatment-free days in between. Treatment cycles may need to be continued for mth or yr until complete eradication of parasites.

Oral Neurocysticercosis Adult: Oral Ascariasis Adult: Oral Hookworm infections Adult: Oral Enterobiasis Adult: Enterobiasis Adult: Oral Strongyloidiasis Adult: Oral Giardiasis Adult: Overdosage Symptomatic and supportive measures are advised.

Contraindications Pregnancy and lactation. Hypersensitivity, liver impairment.

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Special Monitor blood counts and liver function. Administer within 7 Precautions days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease. Adverse Drug GI discomfort, headache, nausea, dizziness, allergic Reactions reactions, pruritus, raised liver enzymes, alopecia and dry mouth.

Bone marrow depression. Drug Interactions Cimetidine increases albendazole metabolism. Serum levels are increased if taken with dexamethasone and praziquantel agent. Mechanism of Albendazole exhibits a broad-spectrum anthelmintic activity Action showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease Echinococcus.

Poorly absorbed from the GI tract oral. Widely distributed; bile, CSF. Extensive hepatic first-pass metabolism; converted to albendazole sulfoxide. Via bile; via urine small amounts. Note that there are some more drugs interacting with albendazole albendazole further details are available in official CIMS India albendazole albendazole brands available in India Always prescribe with Generic Name: Oral Paget's disease of bone Adult: Oral Prophylaxis of postmenopausal osteoporosis Adult: Oral Corticosteroid-induced osteoporosis Adult: Treatment and prevention: Administration Should be taken on an empty stomach.

Overdosage Symptoms may include hypocalcaemia, hypophosphataemia and upper GI adverse events, such as upset stomach, heartburn, esophagitis, gastritis or ulcer. Milk or antacids should be given to bind alendronate. Should not induce vomiting due to the risk of oesophageal irritation. Patient should remain fully upright.

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Dialysis would not be beneficial. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin.

Adverse Drug Oesophagitis, oesophageal ulcers and erosions, dysphagia, Reactions heartburn, retrosternal pain, abdominal pain, distension, diarrhoea, constipation, flatulence, headache, rash, erythema, musculoskeletal pain, transient decreases in serum phosphate.

Drug Interactions Concomitant iron, calcium supplements and antacids hinder alendronate absorption. Food Interaction Food, mineral water, coffee, tea and juice interfere with absorption of alendronate.

Mechanism of Alendronic acid reduces bone resorption by inhibiting the Action action of osteoclasts. Poorly absorbed from the GIT oral ; reduced by food. Used in the treatment of bone diseases. Initially, 1 mcg daily.

Premature infants and neonates: Overdosage Symptoms may include anorexia, lassitude, nausea and vomiting, constipation or diarrhoea, polyuria, nocturia, sweating, headache, thirst, somnolence and vertigo and hypercalcaemia.

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Stop admin of alfacalcidol. Treatment is symptomatic and supportive. Ensure patient is well hydrated by i. Monitor electrolytes, calcium levels, renal function, ECG especially in patients on digitalis. Consider treatment with glucocorticosteroids, loop diuretics, bisphosphonates, calcitonin and haemodialysis with low calcium content. Contraindications Hypercalcaemia, metastatic calcification, hyperphosphataemia except when occurring with hypoparathyroidism , hypermagnesaemia.

Special Pregnancy, lactation, renal impairment, infants, elderly. Monitor Precautions serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. Adverse Drug Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, Reactions sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification.

In case of renal impairment, hyperphosphataemia. In hypercalcaemic dialysis patients, possibility of calcium influx from the dialysate should be considered. Drug Interactions Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D. Mechanism of Alfacalcidol is a precursor of the active calcitriol. It does not Action require renal hydroxylation but requires hydroxylation in the liver for conversion to calcitriol.

Adequately absorbed from the GI tract oral. Adipose and muscle tissue; enters breast milk. Specific to a-globulin. Hepatic; rapidly converted to calcitriol. Faeces and urine small amounts.

Used as dietary supplements. Note that there are some more drugs interacting with alfacalcidol alfacalcidol alfacalcidol brands available in India Always prescribe with Generic Name: Initiate with 2.

Adjust dose according to response. Mild-moderate impairment: Modified-release preparations are not recommended. Overdosage May lead to hypotension. Maintain patient in supine position to restore BP. Monitor renal function. Contraindications Severe hepatic impairment; history of postural hypotension and micturition syncope; intestinal occlusion; severe renal insufficiency; lactation.

Special Elderly; hypertension; coronary insufficiency; angina Precautions discontinue ; renal or hepatic impairment. Monitor BP regularly. May affect ability to drive or operate machinery. Adverse Drug Drowsiness, postural hypotension, syncope, asthenia, Reactions depression, headache, dry mouth, GI disturbances, edema, blurred vision, rhinitis, erectile disorders, tachycardia, palpitation, hypersensitivity reactions; flushes; chest pain; dizziness; lack of energy.

Reduced serum levels when used with CYP3A4 inducers e. Concurrent use with potent CYP3A4 inhibitors e. Mechanism of Alfuzosin is a quinazoline-derivative which exhibits selectivity Action for a1 -adrenergic receptors in the lower urinary tract. Blockade of these adrenoreceptors causes relaxation of smooth muscle in the bladder neck and prostate, resulting in improvement in urine flow and a reduction in symptoms of benign prostatic hyperplasia.

Readily absorbed after oral admin. Extensively metabolised in the liver, mainly by the cytochrome P isoenzyme CYP3A4, to inactive metabolites. Metabolites are mainly excreted in faeces via bile. Used in the treatment of benign prostatic hypertrophy. Note that there are some more drugs interacting with alfuzosin alfuzosin further details are available in official CIMS India alfuzosin alfuzosin brands available in India Always prescribe with Generic Name: Up to mg may be taken as a single dose; larger doses should be taken in divided doses to minimise gastric irritation.

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Max initial dose: Severe impairment: Dose reduction may be needed. Monitor liver function regularly. Oral Gout Adult: Oral Prophylaxis of uric acid nephropathy associated with cancer therapy Adult: Ensure adequate fluid intake.

Maintenance for patients with hyperuricaemia secondary to cancer or cancer therapy: Dose is titrated based on response. Oral Recurrent calcium oxalate stones Adult: Dose is adjusted based on subsequent hr urinary urateexcretion. Intravenous Cancer therapy-induced hyperuricaemia Adult: Therapy should be started hr before initiating the treatment. Ensure sufficient fluid intake to produce a daily urinary output of at least 2 L and maintenance of a neutral, or slightly alkaline urine.

Dose can be given as a single dose or equally divided doses at 6-, 8- or hr intervals; infuse over minutes. Therapy should be started hr before initiating the chemotherapy treatment.

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Amikacin sulfate, amphotericin B, carmustine, cefotaxime sodium, chlormethine hydrochloride, chlorpromazine hydrochloride, cimetidine hydrochloride, clindamycin phosphate, cytarabine, dacarbazine, daunorubicin hydrochloride, diphenhydramine hydrochloride, doxorubicin hydrochloride, doxycycline hyclate, droperidol, floxuridine, gentamicin sulfate, haloperidol lactate, hydroxyzine hydrochloride, idarubicin hydrochloride, imipenem with cilastatin sodium, methylprednisolone sodium succinate, metoclopramide hydrochloride, minocycline hydrochloride, nalbuphine hydrochloride, netilmicin sulfate, ondansetron hydrochloride, pethidine hydrochloride, prochlorperazine edisilate, promethazine hydrochloride, sodium bicarbonate, streptozocin, tobramycin sulfate and vinorelbine tartrate.

Take immediately after meals. Contraindications Hypersensitivity; acute attack of gout. Special Ensure adequate fluid intake. Prophylactically with an Precautions anti-inflammatory or colchicine for at least 1 mth. Withdraw immediately when sensitivity skin rash, etc appears. Adverse Drug Rash; alopoecia; GI disorders, taste disturbances, nausea, Reactions vomiting, abdominal pain, diarrhoea; paraesthesia, peripheral neuropathy, vertigo, headache, hepatic necrosis, drowsiness, neuritis, arthralgia; hypertension.

Occasionally, thrombocytopaenia, agranulocytosis and aplastic anaemia. Drug Interactions Increased risk of skin rash when used with ampicillin or amoxicillin. May prolong half-life of chlorpropamide and dicumarol. May increase serum levels of ciclosporin.

May increase bone marrow depression when used with cyclophosphamide Potentially Fatal: Increased haematological effects of azathioprine and mercaptopurine when co-administered with allopurinol.

Powder for inj: After reconstitution: Solution should be used within 10 hr of preparation. Mechanism of Allopurinol is an inhibitor of the enzyme xanthine oxidase Action which converts hypoxanthine to xanthine then uric acid. The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid, there is no risk of nephrolithiasis.

Enters breast milk. Converted to oxipurinol alloxanthine. Urine as unchanged drug and metabolite , faeces. Used in the treatment of gout. Special Discontinue medications if there is sudden partial or complete loss of vision, Precautions proptosis or diplopia; migraine and embolic disorders; epilepsy, migraine, asth cardiac or renal dysfunction.

History of depression, glucose tolerance and dia patients. My impair ability to drive operate machinery. Sudden withdrawal of allyloestrenol should be avoided as it leads to intermittent breakthrough bleed lactation. Drug Interactions Enhanced clearance with enzyme-inducing drugs eg, carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Ket azole may increase bioavailability of progesterone.

Increased ciclosporin concentration. Lab Interference Alterations in lipid profile and liver function tests. Mechanism of Allylestrenol is similar to that of natural progesterone. It prepares the uterus fo Action receiving the fertilised ovum and suppresses uterine motility.

ATC G03DC01 - allylestrenol; Belongs to the class of estren derivative progestoge Classification used in progestogenic hormone preparations. Note that there are some more drugs interacting with allylestrenol allylestrenol allylestrenol brands available in India Always prescribe with Generic Name: As a racemic mixture: Take 30 mins before meals. Special Pregnancy and lactation. May lower blood glucose. Monitor Precautions blood glucose levels regularly. Mechanism of Alpha-lipoic acid has antioxidant activity and activity in Action enhancing biological energy production.

It is also known as thioctic acid. Initially, 0. Avoid in severe impairment. Oral Panic attacks Adult: Up to 10 mg daily. Somnolence, confusion, impaired coordination, diminished reflexes and coma.

Monitor respiration, pulse rate and BP. General supportive measures and immediate gastric lavage may be recommended. If hypotension occurs, it may be combated by the use of vasopressors. Dialysis is of limited value. Flumazenil may be used for complete or partial reversal of the sedative effects of benzodiazepines and may be used when an overdose with a benzodiazepine is known or suspected.

Contraindications Acute narrow-angle glaucoma, preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; pregnancy, lactation. Special Dosage reduction or gradual withdrawal. Precautions Geriatric or debilitated patients. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency.

Adverse Drug Psychological and physical dependence, withdrawal Reactions syndrome; drowsiness, sedation, vertigo, headache, visual disturbances, GI disturbances, jaundice; fatigue, muscle weakness, ataxia, dizziness, confusion and depression. Blood dyscrasias. Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine anddesipramine. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk e.

Mechanism of Alprazolam has anxiolytic, muscle-relaxant, anticonvulsant, Action antidepressant and sleep-modifying effects. It binds to the? Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation. Well absorbed from the GIT oral ; peak plasma concentrations after hrs. Hepatic; converted to a-hydroxyalprazolam and benzophenone. Urine as unchanged drug and metabolites ; hrs elimination half-life. Used in the management of anxiety, agitation or tension.

D SR-tab , F. To be injected into a large vein, or alternatively through an umbilical artery catheter placed at the ductal opening. Reduce to the lowest dose necessary to maintain response as soon as possible. Intracavernosal Erectile dysfunction Adult: Usual maintenance: For neurogenic origin e. Initially, 1. Intracavernosal Diagnosis of erectile dysfunction Adult: A dose of mcg may also be administered trans-urethrally. Urethral Erectile dysfunction Adult: Initially mcg, may increase to or mcg or reduce to mcg depending on erectile response.

Contraindications Hypersensitivity, hyaline membrane disease. Caution in COPD. Adverse Drug Flushing, bradycardia, hypotension, tachycardia, oedema, Reactions diarrhoea, fever, convulsions, DIC, cortical proliferation of long bones, hypokalaemia, weakening of the wall of ductus arteriosus and pulmonary artery may follow prolonged use; gastric outlet obstruction reported.

Food Interaction Avoid ethanol. Mechanism of Alprostadil causes vasodilation and prevents platelet Action aggregation. It has direct effect on the vascular and ductus arteriosus smooth muscle. When injected along the penile shaft, alprostadil relaxes the trabecular smooth muscle by dilation of the cavernosal arteries. This allows blood flow to the lacunar spaces of the penis. Rapidly metabolised by oxidation during passage through the pulmonary circulation.

Excreted in urine as metabolites within 24 hr. G04BE01 - alprostadil; Belongs to the class of drugs used in erectile dysfunction. Note that there are some more drugs interacting with alprostadil alprostadil further details are available in official CIMS India alprostadil alprostadil brands available in India Always prescribe with Generic Name: For admin within 6 hr of MI: Intravenous Acute massive pulmonary embolism Adult: Total dose: First 10 mg as bolus, followed by infusion of the remainder dose over 2 hr.

Intravenous Acute ischaemic stroke Adult: To be given within 3 hr of the onset of symptoms: Infuse 0. Injection Clearance of central venous lines Adult: Usual dose: Not to exceed a total dose of 4 mg.

Reconstitute by adding 50 ml of sterile water for inj without preservatives to a vial containing 50 mg of drug using a large-bore e. Final concentration: Dopamine, nitroglycerin, heparin and dobutamine.

Dopamine, dobutamine, heparin. Contraindications Recent surgery or trauma, susceptibility to internal bleeding, history of cerebrovascular accident, uncontrolled hypertension, esophageal varices, heavy vaginal bleeding, coagulation defects, aneurysm and poor glycaemic control.

Special Children, elderly. Monitor intracranial Precautions haemorrhage and BP in acute stroke. Renal impairment. Adverse Drug Vomiting, bleeding from puncture sites, gingival tissues and Reactions urinary tract. Haemorrhage esp with previous trauma or unsuspected underlying cause of bleeding, intracerebral bleeding. Drug Interactions Heparin reduces risk of coronary reocclusion. Prostacyclin and nitrates increase plasma alteplase clearance. Increased risk of hemorrhage with warfarin.

Lab Interference May interfere with estimation of plasma fibrinogen and other coagulation tests. Storage Injection: Lyophilised product: Reconstituted solution: Use within 8 hr. Mechanism of Alteplase initiates local fibrinolysis and dissolution of clots by Action binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin. Alteplase initiates local fibrinolysis and dissolution of clots by binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin.

Cleared rapidly from the plasma mainly by hepatic metabolism. S01XA13 - alteplase; Belongs to the class of other agents used as ophthalmologicals.

Note that there are some more drugs interacting with alteplase alteplase alteplase brands available in India Always prescribe with Generic Name: Up to 1 g daily. Oral Hyperphosphataemia in patients with chronic renal failure Adult: Dose is adjusted to the individual patient's requirement.

Contraindications Hypersensitivity to aluminium salts. Adverse Drug Constipation; intestinal obstruction with large doses ; phosphate Reactions depletion may occur with prolonged admin or large doses. Drug Interactions Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine,phosphate supplements, phenytoin, phenothiazines, trientine.

Food Interaction Food decreases gastric emptying time. Mechanism of Alumunium hydroxide acts on the HCl in the stomach by Action neutralization, forming aluminium chloride salt and water. Alumunium hydroxide reacts with hydrochloric acid in the stomach to form soluble aluminium chloride, which is absorbed from the GI tract. Absorbed aluminium is excreted via the urine.

Insoluble aluminium salts formed in the intestines, eg, hydroxides, carbonates, phosphates and fatty acid derivatives, are excreted in the faeces. Used for the treatment of acid-related disorders. Note that there are some more drugs interacting with aluminium hydroxide aluminium hydroxide aluminium hydroxide brands available in India Always prescribe with Generic Name: Oral Prophylaxis of influenza A Adult: Oral Herpes zoster in immunocompromised patients Adult: Oral Parkinson's disease Adult: Lowest effective dose.

Overdosage Cardiac arrest may occur. Epilepsy or other seizure disorders, severe renal impairment and gastric ulceration. Special Patients with CV or liver disease, impaired renal function, Precautions recurrent eczema. Withdrawal of the drug should be gradual. Adverse Drug Seizures, psychosis, hallucinations, confusion, ataxia, heart Reactions failure, depression, orthostatic hypotension, blood dyscrasias, urinary retention, irritability, GI disturbances, anorexia, livedo reticularis, ankle oedema.

Congestive heart failure, convulsions. Drug Interactions Enhances the adverse effects of antimuscarinics and levodopa. CNS stimulants, drugs that raise urinary pH. Mechanism of Amantadine is a weak dopamine agonist possessing Action antimuscarinic properties. It alters dopamine release and re-uptake. It also noncompetitively antagonises N-methyl-D-aspartate.

As an antiviral drug, it inhibits replication of influenza type A virus. Readily absorbed from the GIT oral ; peak concentrations after 4 hrs. Crosses the placenta and the blood-brain barrier; enters breast milk. Mainly via urine by glomerular filtration and tubular secretion as unchanged and small amounts of an acetylated metabolite ; hrs elimination half-life , significantly prolonged in the elderly and renal impairment; may be increased by acidification of the urine.

Used in the management of parkinson's disease. Note that there are some more drugs interacting with amantadine amantadine amantadine brands available in India Always prescribe with Generic Name: Adverse Drug Mild GI effects and allergic reactions. Reactions Mechanism of Ambroxol is a metabolite of bromhexine and is used Action similarly as a mucolytic.

Used in the treatment of wet cough. Intravenous Prophylaxis of xerostomia in patients undergoing radiotherapy for head and neck cancer Adult: Each single-use vial contains mg of anhydrous amifostine. Reconstitute with 9. Visual inspection for particulate matter and discoloration prior to admin is recommended.

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